ORIGINS: WHAT MADE EUKARYOTES REPRODUCE SEXUALLY? July 27, 2022
08:30 - 09:00
Registration |
09:00 - 09:10
Welcome address - Mónica Bettencourt-Dias - Sarah Otto - Antoine Molaro - Paulo Navarro-Costa |
Session 1:
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Session 1:
THE ORIGIN AND MAINTENANCE OF SEX
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09:10 - 09:50
The evolutionary enigma of sex. Sarah Otto (University of British Columbia, Canada) |
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09:50 - 10:15
Selected Talk: Genomic causes and consequences of asexuality in Schmidtea mediterranea. Jeremias Brand (Max Planck Institute for Multidisciplinary Sciences, Germany) |
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10:15 - 10:40
Selected talk: Meiotic sex: the key to genomic integrity in ancestral eukaryotes. Marco Colnaghi (University College London, UK) |
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10:40 - 11:00
Morning Break |
Session 2:
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Session 2:
TWO TO TANGO: SEX AND DIVERSITY
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11:00 - 11:40
The causes and consequences of haploid gametic selection in 'diploid' organisms. Simone Immler (University of East Anglia, UK) |
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11:40 - 12:05
Selected talk: On how meiosis can shape sex chromosome evolution. Aurora Ruiz-Herrera (Institut de Biotecnologia i Biomedicina, Barcelona) |
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12:05 - 12:30
Selected talk: DNA repair during non-reductional meiosis in the asexual rotifer Adineta vaga. Karine Van Doninck (University of Namur, Belgium) |
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12:30 - 14:30
Lunch |
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14:30 - 15:00
Flash Presentations |
Session 3:
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Session 3:
SHIFTING SANDS – THE EVOLUTION OF MEIOTIC PROCESSES
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15:00 - 15:40
The evolution of germline and somatic X-dosage compensation. James Turner (Francis Crick Institute, UK) |
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15:40 - 16:05
Selected talk: Conserved meiotic mechanisms in the cnidarian Clytia hemisphaerica revealed by Spo11 knockout. Jean-René Huynh (Collège de France) |
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16:05 - 16:30
Selected talk: Polycomb group proteins prevent the assembly of alternative synaptonemal complex structures during meiosis. Rui Martinho (University of Aveiro, Portugal) |
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16:30 - 17:00
Afternoon break |
Session 4:
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Session 4:
SEX CHROMOSOME EVOLUTION
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17:00 - 17:40
Tales of the Y chromosome: heterochromatin, aging & meiotic conflicts. Doris Bachtrog (University of California Berkley, USA) |
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17:40 - 18:05
Selected talk: Battle of the sex chromosomes: competition between X- and Y-chromosome encoded proteins for partner interaction and chromatin occupancy drives multi-copy gene expression in mouse gametes. Julie Cocquet (Institut Cochin, France) |
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18:05 - 18:30
Selected talk: Meiotic drive and suppression: de novo protamine copies and hairpin RNAs fuel intragenomic arms races in the male germline. Jeffrey Vedanayagam (Sloan-Kettering Institute, USA) |
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18:30
Wine, Posters & Cheese Session |
EVOLUTION: WHAT ARE THE CONSTRAINTS THAT SHAPE REPRODUCTION? July 28, 2022
Session 5:
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Session 5:
HOW CONSTRAINTS AND INTERACTIONS SHAPE GERM CELL EVOLUTION
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09:00 - 09:40
Open questions in germ line evolution: where do we go from here? Cassandra Extavour (Harvard University, USA) |
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09:40 - 10:05
Selected talk: Adaptation of Caenorhabditis elegans populations to different reproductive schedules depends on interacting bacteria. Ivo Chelo (University of Lisbon, Portugal) |
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10:05 - 10:30
Selected talk: Understanding genetic variation in sperm via the sperm proteome. Jayme Cohen (University of East Anglia, UK) |
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10:30 - 10:50
Morning break |
Session 6:
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Session 6:
ANCIENT ORIGINS OF INFERTILITY
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10:50 - 11:30
The conserved genetic program of male germ cells. Paulo Navarro-Costa (Lisbon Medical School, Portugal) |
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11:30 - 11:55
Selected talk: 3D chromatin remodeling modulates evolutionary plasticity in the germ line. Peter Ellis (University of Kent, UK) |
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11:55 - 12:35
Special guest talk: Causes and consequences of centromere drive. Harmit Malik (Fred Hutchinson Cancer Research Center, USA) |
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12:35 - 14:45
Lunch |
Session 7:
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Session 7:
HOW GERM CELLS BECOME GAMETES
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14:45 - 15:25
Centrioles in development and evolution: tiny organelles, multiple and critical functions. Mónica Bettencourt-Dias (Gulbenkian Science Institute, Portugal) |
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15:25 - 15:50
Selected talk: Where does DNA damage occur during mouse spermatogenesis? Frances Burden (University of Kent, UK) |
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15:50 - 16:10
Afternoon break |
Session 8:
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Session 8:
THE ARMS RACE FOR IMMORTALITY
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16:10 - 16:50
Unusual histones mediate (epi)genetic conflicts during reproduction. Antoine Molaro (Genetic, Reproduction and Development Institute, France) |
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16:50 - 17:15
Selected talk: Safeguarding paternal chromosome identity in the fly zygote. Benjamin Loppin (ENS de Lyon, France) |
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17:15 - 17:40
Selected talk: Interspecies mouse hybrids as a model to study functional consequences of rapid centromere evolution. Piero Lamelza (University of Pennsylvania, USA) |
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17:40 - 19:00
Round-table discussion |
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19:00 - 22:00
Dinner reception |
INFERTILITY: CAN THE PAST INFORM US ABOUT THE FUTURE? July 29, 2022
Session 9:
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Session 9:
TOUCHING FROM A DISTANCE: CELL FUSION
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09:30 - 10:10
Insights on the evolution of gamete interaction from AI-ded structural biology. Luca Jovine (Karolinska Institute, Sweden) |
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10:10 - 10:35
Selected talk: Biochemical characterization of a protein-protein interaction mediating species-specific fertilization in abalone. Jolie Carlisle (Cornell University, USA) |
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10:35 - 11:00
Selected talk: Inbreeding avoidance at the gamete level in Atlantic salmon (Salmo salar). Marco Graziano (University of East Anglia, UK) |
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11:00 - 11:30
Morning break |
Session 10:
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Session 10:
AN EVOLUTIONARY PERSPECTIVE ON MAKING GERM CELLS IN VITRO
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11:30 - 12:10
Novel tools for the study of human spermatogenesis, and the potential options for the clinics. Jan-Bernd Stukenborg (Karolinska Institute, Sweden) |
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12:10 - 12:35
Selected talk: Organoids to model gonadal development in vitro. João Pedro Alves-Lopes (Karolinska Institute, Sweden) |
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12:35 - 14:00
Lunch |
Session 11:
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Session 11:
LIVE LONG OR PROSPER: GERM CELLS VS LIFESPAN
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14:00 - 15:00
Live long or prosper? Reproduction, lifespan and evolutionary fitness in humans. Virpi Lummaa (University of Turku, Finland) |
Session 12:
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Session 12:
EVOLUTIONARY MEDICINE: NEW PERSPECTIVES ON THE FETAL-MATERNAL RELATIONSHIP
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15:00 - 15:40
New perspectives on the fetal-maternal relationship in mammals. Günter Wagner (Yale University, USA) |
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15:40 - 16:05
Selected talk: Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility. Jukka Kekalainen (University of Eastern Finland)
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16:05 - 17:00
Final Remarks |